SUMMARY OBJECTIVE: The aim of this study was to investigate the correlation between the Trial of Org 10172 in acute stroke treatment classification and the National Institutes of Health Stroke Scale score of acute cerebral infarction as well as acute cerebral infarction's risk factors. METHODS: The clinical data of 3,996 patients with acute cerebral infarction hospitalized in Hebei Renqiu Kangjixintu Hospital from January 2014 to November 2018 were analyzed retrospectively. According to Trial of Org 10172 in acute stroke treatment, they were divided into five groups: arteriosclerosis, cardio cerebral embolism, arterial occlusion, other causes, and unknown causes. Through questionnaire design, routine physical examination, and physical and chemical analysis of fasting venous blood samples, the risk factors were evaluated, and the correlation between Trial of Org 10172 in acute stroke treatment classification and National Institutes of Health Stroke Scale classification was analyzed using multivariate logistic regression. In addition, the relationship between National Institutes of Health Stroke Scale score and risk factors in different groups was compared, and the correlation between Trial of Org 10172 in acute stroke treatment classification and National Institutes of Health Stroke Scale score was analyzed. RESULTS: Multivariate logistic regression analysis showed that diabetes, atrial fibrillation or stroke history, age, and education level were related to Trial of Org 10172 in acute stroke treatment classification. In the National Institutes of Health Stroke Scale comparison, the scores of the cardio cerebral embolism group were significantly higher than those of the other four groups, and patients with diabetes, atrial fibrillation, or stroke history had a high share, especially atrial fibrillation (33.06%). CONCLUSIONS: The nerve function defect is more serious after acute cerebral infarction with cardiogenic cerebral embolism, indicating a poor prognosis.

SUMMARY OBJECTIVE: This study aimed to develop and validate a practical nomogram to predict the occurrence of post-traumatic hydrocephalus in patients who have undergone decompressive craniectomy for traumatic brain injury. METHODS: A total of 516 cases were enrolled and divided into the training (n=364) and validation (n=152) cohorts. Optimal predictors were selected through least absolute shrinkage and selection operator regression analysis of the training cohort then used to develop a nomogram. Receiver operating characteristic, calibration plot, and decision curve analysis, respectively, were used to evaluate the discrimination, fitting performance, and clinical utility of the resulting nomogram in the validation cohort. RESULTS: Preoperative subarachnoid hemorrhage Fisher grade, type of decompressive craniectomy, transcalvarial herniation volume, subdural hygroma, and functional outcome were all identified as predictors and included in the predicting model. The nomogram exhibited good discrimination in the validation cohort and had an area under the receiver operating characteristic curve of 0.80 (95%CI 0.72–0.88). The calibration plot demonstrated goodness-of-fit between the nomogram’s prediction and actual observation in the validation cohort. Finally, decision curve analysis indicated significant clinical adaptability. CONCLUSION: The present study developed and validated a model to predict post-traumatic hydrocephalus. The nomogram that had good discrimination, calibration, and clinical practicality can be useful for screening patients at a high risk of post-traumatic hydrocephalus. The nomogram can also be used in clinical practice to develop better therapeutic strategies.

OBJECTIVES: This study investigated whether tissue Doppler imaging parameters, especially the peak systolic velocity of the left ventricular lead-implanted segment (Ss), affect cardiac resynchronization therapy response. METHODS: In this case-control study, 110 enrolled patients were divided into cases (responder group, n=65) and controls (nonresponder group, n=45) based on whether their left ventricular end-systolic volume was reduced by ≥15% at 6 months after surgery. Preoperative clinical and echocardiographic data were collected. Multivariate logistic regression models were used to analyze the factors affecting the response to cardiac resynchronization therapy, and receiver operating characteristic curves were plotted to evaluate their diagnostic values. RESULTS: The proportion of patients with left bundle branch block in the case group was higher than that in the control group. The control group showed a higher left atrial volume index, E/A ratio and E/Em ratio but lower Ss than that of the case group. A multivariate regression analysis showed that left bundle branch block, Ss, and an E/Em ratio>14 were independent risk factors affecting the response to cardiac resynchronization therapy. Ss=4.1 cm/s was the best diagnostic threshold according to the receiver operating characteristic curve. CONCLUSIONS: Ss is an important factor affecting the response to cardiac resynchronization therapy. Patients with heart failure associated with Ss<4.1 cm/s have a higher risk of nonresponse.

摘要 目的 估计中国儿童虐待的健康和经济负担。 方法 我们使用PubMed、Embase、PsycInfo、CINAHL-EBSCO、ERIC和中国国家知识基础设施数据库（中国知网）对中国儿童虐待研究做了系统回顾。我们对符合纳入标准的研究进行荟萃分析，估计儿童忽视和儿童身体、情感以及性虐待流行率。我...

Résumé Objectif Estimer la charge sanitaire et économique de la maltraitance des enfants en Chine. Méthodes Nous avons réalisé une revue systématique des études sur la maltraitance des enfants en Chine en utilisant les bases de données PubMed, Embase, PsycInfo, CINAHL-EBSCO, ERIC et de l'Infrastructure nationale de connaissances chinoises. Nous avons effectué les méta-analyses des études qui satisfaisaient les critères d'inclusion, afin d'estimer la prévalence de l'abandon moral des enfants et des abus physiques, psychologiques et sexuels des enfants. Nous avons utilisé les données des estimations 2010 de la charge mondiale de morbidité pour calculer l'espérance de vie corrigée de l'incapacité (EVCI) perdue du fait de la maltraitance des enfants. Résultats À...

Резюме Цель Оценить влияние бремени жестокого обращения с детьми в Китае на состояние здоровья и экономику. Методы С помощью сведений, полученных из баз...

Objective To estimate the health and economic burdens of child maltreatment in China. Methods We did a systematic review for studies on child maltreatment in China using PubMed, Embase, PsycInfo, CINAHL-EBSCO, ERIC and the Chinese National Knowledge Infrastructure databases. We did meta-analyses of studies that met inclusion criteria to estimate the prevalence of child neglect and child physical, emotional and sexual abuse. We used data from the 2010 global burden of disease estimates to calculate disability-adjusted life-years (DALYs) lost as a result of child maltreatment. Findings From 68 studies we estimated that 26.6% of children under 18 years of age have suffered physical abuse, 19.6% emotional abuse, 8.7% sexual abuse and 26.0% neglect. We estimate that emotional abuse in childhood accounts for 26.3% of the DALYs lost because of mental disorders and 18.0% of those lost because of self-harm. Physical abuse in childhood accounts for 12.2% of DALYs lost because of depression, 17.0% of those lost to anxiety, 20.7% of those lost to problem drinking, 18.8% of those lost to illicit drug use and 18.3% of those lost to self-harm. The consequences of physical abuse of children costs China an estimated 0.84% of its gross domestic product – i.e. 50 billion United States dollars – in 2010. The corresponding losses attributable to emotional and sexual abuse in childhood were 0.47% and 0.39% of the gross domestic product, respectively. Conclusion In China, child maltreatment is common and associated with large economic losses because many maltreated children suffer substantial psychological distress and might adopt behaviours that increase their risk of chronic disease.

ملخص الغرض تقدير الأعباء الصحية والاقتصادية لإساءة معاملة الأطفال في الصين. الطريقة أجرينا استعراضاً منهجياً للدراسات المعنية بإساءة معاملة الأطفال في...

Resumen Objetivo Estimar la carga sanitaria y económica del maltrato infantil en China. Métodos Se realizó una revisión sistemática de los estudios sobre el maltrato infantil en China utilizando las bases de datos PubMed, Embase, PsycInfo, CINAHL-EBSCO, ERIC y Chinese National Knowledge Infrastructure. También se efectuó un metaanálisis de los estudios que cumplieron los criterios de inclusión para estimar la prevalencia del abandono infantil y del abuso infantil físico, emocional y sexual. Se emplearon datos de las estimaciones de la carga mundial de morbilidad del año 2010 para calcular los años de vida ajustados por discapacidad (AVAD) perdidos como consecuencia del maltrato infantil. Resultados A partir de 68 estudios se estimó que el 26,6 % de los niños menores de 18 años de edad han sufrido abuso físico, el 19,6 % abuso emocional, el 8,7 % abuso sexual y el 26,0 % abandono. Asimismo, se estimó que el abuso emocional en la infancia representa el 26,3 % de los AVAD perdidos a causa de trastornos mentales y el 18,0 % de los perdidos por autolesión. El abuso físico en la infancia representa el 12,2 % de los AVAD perdidos a causa de la depresión, el 17,0 % por ansiedad, el 20,7 % por problemas con el alcohol, el 18,8 % por uso de drogas ilícitas y el 18,3 % por autolesión. Las consecuencias del abuso físico de niños le cuestan a China aproximadamente el 0,84 % de su producto interior bruto, es decir, 50 mil millones de dólares de los Estados Unidos, en 2010. Las pérdidas correspondientes atribuibles al abuso emocional y sexual en la infancia representaron el 0,47 % y el 0,39 % del producto interior bruto, respectivamente. Conclusión En China, el maltrato infantil es común y está asociado con grandes pérdidas económicas, ya que muchos niños maltratados sufren trastornos psicológicos importantes y podrían adoptar conductas que aumentan su riesgo de sufrir enfermedades crónicas.

Microbial degradation of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) is the most promising way to clean up DDT residues found in the environment. In this paper, a bacterium designated as wax, which was capable of co-metabolizing DDT with other carbon sources, was isolated from a long-term DDT-contaminated soil sample by an enrichment culture technique. The new isolate was identified as a member of the Pseudoxanthomonas sp., based on its morphological, physiological and biochemical properties, as well as by 16S rRNA gene analysis. In the presence of 100 mg l-1 glucose, the wax strain could degrade over 95% of the total DDT, at a concentration of 20 mg l-1, in 72 hours, and could degrade over 60% of the total DDT, at a concentration of 100 mg l-1, in 144 hours. The wax strain had the highest degradation efficiency among all of the documented DDT-degrading bacteria. The wax strain could efficiently degrade DDT at temperatures ranging from 20 to 37ºC, and with initial pH values ranging from 7 to 9. The bacterium could also simultaneously co-metabolize 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD), 2,2-bis(p-chlorophenyl)-1,1-dichlorethylene (DDE), and other organochlorine compounds. The wax strain could also completely remove 20 mg kg-1 of DDT from both sterile and non-sterile soils in 20 days. This study demonstrates the significant potential use of Pseudoxanthomonas sp. wax for the bioremediation of DDT in the environment.